Tab GERD: Erosive reflux esophagitis Adult & childn 12-18 yr 40 mg once daily for 4-8 wk.
Childn 1-11 yr weighing ≥20 kg 10-20 mg once daily for 8 wk,
<20 kg 10 mg once daily for 8 wk.
Long-term management of patient w/ healed esophagitis to prevent relapse Adult & childn 12-18 yr 20 mg once daily.
Childn 1-11 yr 10 mg once daily.
Symptomatic treatment of GERD in patient w/o esophagitis Adult & childn 12-18 yr 20 mg once daily for 4 wk.
Adult Upper GI symptoms associated w/ NSAID therapy 20 mg once daily for 4 wk.
Healing of gastric ulcers associated w/ NSAID therapy 20-40 mg once daily for 4-8 wk.
Prevention of gastric &/or duodenal ulcers associated w/ NSAID therapy or low dose aspirin in patient at risk 20-40 mg once daily.
Maintenance of hemostasis & prevention of rebleeding of gastric or duodenal ulcers 40 mg once daily for 4 wk. The oral treatment period should be preceded by acid-suppression therapy w/ esomeprazole IV 80 mg administered as bolus infusion over 30 min followed by a continuous IV infusion of 8 mg/hr given over 3 days.
In combination w/ an appropriate antibacterial therapeutic regimen for the eradication of H. pylori 20 mg w/ amoxicillin 1 g & clarithromycin 500 mg, all bid for 7 days.
Pathological hypersecretory conditions including Zollinger-Ellison syndrome & idiopathic hypersecretion Initially 40-120 mg bid.
Childn 12-18 yr Duodenal ulcer caused by
H. pylori 20 mg bid. Duration: Most commonly 7 days but may be up to 14 days.
Childn 1-11 yr Symptomatic treatment of GERD 10 mg once daily for up to 8 wk.
Severe liver impairment Max: 20 mg daily.
Granules for oral susp Erosive reflux esophagitis Childn 1-11 yr weighing ≥20 kg 10-20 mg once daily for 8 wk,
<20 kg 10 mg once daily for 8 wk.
Long-term management of patient w/ healed esophagitis to prevent relapse 10 mg once daily.
Symptomatic treatment of GERD 10 mg once daily for up to 8 wk.
GERD diagnostically confirmed through pH probe or endoscopy Childn 1-11 mth weighing >7.5-12 kg 10 mg,
>5-7.5 kg 5 mg,
3-5 kg 2.5 mg, all doses to be taken once daily for up to 6 wk.
Childn 0-1 mth weighing ≥2.5 kg 2.5 mg once daily for up to 4 wk.
Severe liver impairment Max: 20 mg daily.
Inj Erosive reflux esophagitis Adult & childn 12-17 yr 40 mg once daily.
Childn 1-11 yr weighing ≥20 kg 10-20 mg once daily,
<20 kg 10 mg once daily,
1-11 mth 1 mg/kg once daily,
0-1 mth 0.5 mg/kg once daily.
Adult Long-term management of patient w/ healed esophagitis to prevent relapse 20 mg once daily.
Symptomatic treatment of GERD Adult 20 mg once daily in patient w/o esophagitis.
Childn 12-17 yr 20 mg once daily,
1-11 yr 10 mg once daily,
1-11 mth 1 mg/kg once daily,
0-1 mth 0.5 mg/kg once daily.
Adult Healing of gastric ulcers associated w/ NSAID therapy 20 mg once daily.
Prevention of gastric & duodenal ulcers associated w/ NSAID therapy in patient at risk 20 mg once daily.
Maintenance of hemostasis & prevention of rebleeding of gastric or duodenal ulcers 80 mg as bolus infusion over 30 min followed by continuous IV infusion of 8 mg/hr given over 3 days. Parenteral treatment should be followed by 40-mg tab once daily for 4 wk.
Severe liver impairment GERD Max: 20 mg daily.
Bleeding ulcers Initial bolus: 80 mg, followed by continuous IV infusion of 4 mg/hr.
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